TGF-β Alters the Proportion of Infiltrating Immune Cells in a Pancreatic Ductal Adenocarcinoma.
Kasia Trebska-McGowanMehdi ChaibMarcus A AlvarezRita KansalAjeeth K PingiliDavid ShibataLiza MakowskiEvan S GlazerPublished in: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract (2021)
TGF-β is important in PDAC anti-tumor immunity, demonstrating context-dependent impact on immune cells. TGF-β has an overall immunosuppressive effect mediated by TAM PD-L1 expression and decreased presence of DCs. Future investigations will focus on enhancing anti-cancer immune effects of TGF-β receptor inhibition.