Human EGFRvIII chimeric antigen receptor T cells demonstrate favorable safety profile and curative responses in orthotopic glioblastoma.

Rebecca C Abbott Melinda Iliopoulos Katherine A Watson Valeria Arcucci Margareta Go Hannah E Hughes-ParryPete SmithMelissa J Call Ryan S Cross Misty R Jenkins

Published in: Clinical & translational immunology (2023)

This study demonstrates the preclinical functionality of a highly specific CAR targeting EGFRvIII on human cells. This CAR could be an effective treatment for glioblastoma and warrants future clinical investigation.

Keyphrases

current status
cancer therapy
cell therapy
rectal cancer
bone marrow
mesenchymal stem cells