Cryptotanshinone Reverses Corticosteroid Insensitivity by Inhibition of Phosphoinositide-3-Kinase-δ in Chronic Obstructive Pulmonary Disease.

Tao XieRong HuangDaishuo Deng Peipei TangYufeng FuYulong ZhengYufeng Wan

Published in: International journal of chronic obstructive pulmonary disease (2023)

Cryptotanshinone restores corticosteroid sensitivity induced by oxidative stress via inhibition of PI3Kδ and is a potential treatment for corticosteroid-insensitive diseases such as COPD.

Keyphrases

oxidative stress
chronic obstructive pulmonary disease
cystic fibrosis
induced apoptosis
tyrosine kinase
human health
risk assessment
protein kinase
smoking cessation
heat shock
signaling pathway