Identification and Functional Characterization of a Novel Susceptibility Locus for Small Vessel Vasculitis with MPO-ANCA.

Johanna DahlqvistDiana EkmanBengt SennbladSergey V KozyrevJessika NordinÅsa KarlssonJennifer R S MeadowsErik HellbacherSolbritt Rantapää-DahlqvistEwa BerglinBernd StegmayrBo BaslundØyvind PalmHilde HaukelandIva GunnarssonAnnette BruchfeldMårten SegelmarkSophie OhlssonAladdin J MohammadAnna SvärdRille PulleritsHans HerlitzAnnika SöderberghGerli Rosengren PielbergLina Hultin RosenbergMatteo BianchiEva MurénRoald OmdalRoland JonssonMaija-Leena ElorantaLars RönnblomPeter SöderkvistAnn KnightPer ErikssonKerstin Lindblad-Toh

Published in: Rheumatology (Oxford, England) (2021)

We identified a novel susceptibility locus for MPO-ANCA+ AAV and propose that the associated variant is of mechanistic importance, exerting a regulatory function on gene expression in specific cell types.

Keyphrases

gene expression
single cell
dna methylation
genome wide association study
cell therapy
transcription factor
gene therapy
mesenchymal stem cells