Brief Report: Circulating Cytokine Profiles and Antineutrophil Cytoplasmic Antibody Specificity in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.

Alvise BertiRoscoe WarnerKent JohnsonDivi CornecDarrell SchroederBrian KabatCarol A LangfordGary S HoffmanFernanado C FervenzaCees G M KallenbergPhilip SeoRobert SpieraE William St ClairPaul BrunettaJohn H StonePeter A MerkelUlrich SpecksPaul A Monachnull null

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2018)

Distinct cytokine profiles were identified for PR3-AAV versus MPO-AAV and for GPA versus MPA. Differences in these circulating immune mediators are more strongly associated with ANCA specificity than with clinical diagnosis, suggesting that heterogeneity in the AAV subtypes extends beyond clinical phenotypes.

Keyphrases

gene therapy
structural basis