Bioactive Cembranoids from the Coral Sarcophyton trocheliophorum of Ximao Island.

Eight new cembranoids (sarcophytembranoids A-H, 1 - 8 ) and 10 known terpenoids ( 9 - 18 ) were obtained from the soft coral Sarcophyton trocheliophorum of Ximao Island. Notably, 11 , 15 , and 16 were obtained from a natural source for the first time. The structures of the new isolates were elucidated by extensive spectroscopic analysis, optical rotatory dispersion, and X-ray diffraction experiments. Although the isolated compounds did not show significant activity against the tested tumor cell lines, compounds 3 , 7 , 8 , and 10 - 15 exhibited anti-inflammatory activities at 10 μM, and compounds 17 and 18 showed moderate protein tyrosine phosphatase 1B inhibition activities with the minimum inhibitory concentrations of 22.19 and 11.26 μM, respectively.