Primary high-grade serous ovarian cancer cells are sensitive to senescence induced by carboplatin and paclitaxel in vitro.

Paweł UruskiAgnieszka SepetowskaCorinna KoniecznaMartyna PakułaMichał WyrwaAkylbek TussupkaliyevAndrzej TykarskiJustyna Mikuła-PietrasikKrzysztof Książek

Published in: Cellular & molecular biology letters (2021)

Our findings imply that conventional chemotherapy may elicit senescence in ovarian cancer cells, which may translate to the development of a cancer-promoting phenotype, despite the inability of these cells to divide.

Keyphrases

high grade
low grade
induced apoptosis
dna damage
endothelial cells
papillary thyroid
cell cycle arrest
stress induced
phase ii study
locally advanced
oxidative stress
cell death
chemotherapy induced
signaling pathway
squamous cell carcinoma
radiation therapy
phase iii