COBRAPed cohort: Do sensitization patterns differentiate children with severe asthma from those with a milder disease?
Stéphanie LejeuneNaïm BouazzaPascale Roland NicaiseValérie JolaineLéa RoditisChristophe MarguetFlore AmatPatrick BergerMichael FayonJean-Christophe DubusSophie ValoisPhilippe ReixMathieu PellanJacques BrouardRaphael ChironLisa Giovannini-ChamiJacques de BlicAntoine DeschildreGuillaume Lezminull nullPublished in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2024)
Although children with wheeze/asthma display frequent occurrences and high levels of sensitization, sensitization patterns did not provide strong signals to discriminate children with severe disease from those with milder disease. These results suggest that the severity of wheeze/asthma may depend on both IgE- and non-IgE-mediated mechanisms.