Genome-wide analysis of DNA methylation in buccal cells: a study of monozygotic twins and mQTLs.
Jenny Van DongenErik A EhliRick JansenCatharina E M van BeijsterveldtGonneke WillemsenJouke J HottengaNoah A KallsenShanna A PeytonCharles E BreezeCornelis KluftBastiaan T HeijmansMeike BartelsGareth E DaviesDorret I BoomsmaPublished in: Epigenetics & chromatin (2018)
We conclude that the contribution of familial factors to individual differences in DNA methylation and the effect of mQTLs are larger for novel EPIC probes, especially those within regulatory elements connected to active regions specific to the investigated tissue.
Keyphrases
- dna methylation
- genome wide analysis
- genome wide
- induced apoptosis
- gene expression
- cell cycle arrest
- small molecule
- transcription factor
- early onset
- copy number
- endoplasmic reticulum stress
- single molecule
- signaling pathway
- oxidative stress
- cell death
- atomic force microscopy
- fluorescence imaging
- cell proliferation
- living cells
- mass spectrometry
- high resolution