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Use of pragmatic randomized trials in multiple sclerosis: A systematic overview.

Julian HirtPerrine JaniaudPascal DüblinGiovanni Jacopo NicolettiKinga DembowskaThao Vy Thi NguyenTim WoelfleCathrine AxforsÖzgür YaldizliCristina GranzieraJens KuhleLudwig KapposLars G Hemkens
Published in: Multiple sclerosis (Houndmills, Basingstoke, England) (2024)
Only few and mostly small pragmatic trials exist in MS which rarely assess drugs. Despite the widely available routine data infrastructures, very few trials utilize them. There is an urgent need to leverage the potential of this pioneering study design to provide useful randomized real-world evidence.
Keyphrases
  • multiple sclerosis
  • study protocol
  • double blind
  • open label
  • white matter
  • mass spectrometry
  • placebo controlled
  • electronic health record
  • phase iii
  • ms ms
  • phase ii
  • clinical trial
  • human health
  • data analysis
  • drug induced