The Co-mutational Spectrum Determines the Therapeutic Response in Murine FGFR2 Fusion-Driven Cholangiocarcinoma.
Gajanan KendreSilke MarhenkeGeorgina LorzDiana BeckerTanja Reineke-PlaaßTanja PothKarthikeyan MurugesanFlorian KühnelNorman WollerRalph M WirtzAndreas PichJens U MarquardtMichael SaborowskiArndt VogelAnna SaborowskiPublished in: Hepatology (Baltimore, Md.) (2021)
Our work highlights the importance of the co-mutational spectrum as a significant modifier of response in tumors that harbor potent oncogenic drivers. A better understanding of the genetic underpinnings of resistance will be pivotal to improve biomarker-guided patient selection and to design clinically relevant combination strategies.