MRSA strains with distinct accessory genes predominate at different ages in cystic fibrosis.
Harry S PorterfieldLucas J MaakestadMason M LaMarcheAndrew L ThurmanZoe E KienenbergerNicholas J PitcherAlexis R HansenChristian F ZirbesLinda BoykenBethany L MuyskensAlejandro A PezzuloSachinkumar B SinghErik TwaitBradley FordDaniel J DiekemaValérie ReebAnthony J FischerPublished in: Pediatric pulmonology (2021)
In this CF cohort, we identified MRSA subtypes that predominate at different ages and differ by accessory gene content. The most prevalent cluster of MRSA, including ST5 and ST105, was associated with lower FEV1 . ST8 MRSA was more common in younger patients and thus has the potential to rise in prevalence as these patients age.
Keyphrases
- cystic fibrosis
- end stage renal disease
- methicillin resistant staphylococcus aureus
- staphylococcus aureus
- ejection fraction
- newly diagnosed
- chronic kidney disease
- escherichia coli
- peritoneal dialysis
- prognostic factors
- risk factors
- gene expression
- risk assessment
- patient reported outcomes
- transcription factor
- climate change
- air pollution
- lung function