Commensal microbe-derived acetate suppresses NAFLD/NASH development via hepatic FFAR2 signalling in mice.

Ryo AokiMasayoshi OnukiKoya HattoriMasato ItoTakahiro YamadaKohei KamikadoYun-Gi KimNobuhiro NakamotoIkuo KimuraJulie M ClarkeTakanori KanaiKoji Hase

Published in: Microbiome (2021)

These findings demonstrated that the commensal microbiome-acetate-FFAR2 molecular circuit improves insulin sensitivity in the liver and prevents the development of NAFLD/NASH. Video abstract.

Keyphrases

signaling pathway
type diabetes
metabolic syndrome
high fat diet induced
single molecule