Duration of Adjuvant Doublet Chemotherapy (3 or 6 months) in Patients With High-Risk Stage II Colorectal Cancer.
Timothy J IvesonAlberto F SobreroTakayuki YoshinoIoannis SouglakosFang-Shu OuJeffrey P MeyersQian ShiAxel GrotheyMark P SaundersRoberto LabiancaTakeharu YamanakaIoannis BoukovinasNiels Henrik HollanderFabio GalliKentaro YamazakiVassilis GeorgouliasRachel KerrEiji OkiSara LonardiAndrea HarkinGerardo RosatiJames PaulPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2021)
Although noninferiority has not been demonstrated in the overall population, the convenience, reduced toxicity, and cost of 3-month adjuvant CAPOX suggest it as a potential option for high-risk stage II colon cancer if oxaliplatin-based chemotherapy is suitable. The relative contribution of the factors used to define high-risk stage II disease needs better understanding.