Mismatch repair deficiency and microsatellite instability in urothelial carcinoma: a systematic review and meta-analysis.

Elias B A ChandranGiovanni Maria IannantuonoSaad O AtiqDilara AkbulutNinet SinaiiNicholas I SimonAbdul Rouf BandaySalah BoudjadiSandeep GurramAmin H NassarJonathan E RosenbergGisela ButeraMin Yuen TeoGuru P SonpavdeJonathan A ColemanAndrea B Apolo

Published in: BMJ oncology (2024)

Both dMMR and MSI-H occur more frequently in UTUC than in BC. In UC, MSI-H occurs more frequently in localised disease than in metastatic disease. These biomarkers may predict sensitivity to ICI in metastatic UC and resistance to cisplatin-based chemotherapy.

Keyphrases

squamous cell carcinoma
small cell lung cancer
locally advanced
radiation therapy
replacement therapy
rectal cancer
smoking cessation