Cytomegalovirus DNA detection in pregnant women with a high IgG avidity index: a valuable tool for diagnosing non-primary infections?

Ioulia KarageorgouAthanasios KossyvakisJuan JiménezIrene GarciaAlexios-Fotios A Mentis

Published in: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (2022)

CMV DNA was present in 2.4% of seropositive women with high IgG AI, indicating active NPI and thus, harboring the risk of cCMV sequelae to the fetus. Moreover, the incidence of NPI may have been underestimated due to single timepoint testing. In order to detect CMV NPI in a seropositive woman, regular and frequent serology testing as well as detection of CMV DNAemia are required which render the whole diagnostic process impractical and not cost-effective.

Keyphrases

pregnant women
circulating tumor
loop mediated isothermal amplification
cell free
single molecule
real time pcr
label free
risk factors
artificial intelligence
epstein barr virus
nucleic acid
machine learning
circulating tumor cells
diffuse large b cell lymphoma