CreLite: An optogenetically controlled Cre/loxP system using red light.

Shuo-Ting YenKenneth A TrimmerNader Aboul-FettouhRachel D MullenJames C CulverMary E DickinsonRichard R BehringerGeorge T Eisenhoffer

Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2020)

Our data show that CreLite can be used for gene manipulations in whole embryos or small groups of cells at different developmental stages, and suggests CreLite may also be useful for temporal and spatial control of gene expression in cell culture, ex vivo organ culture, and other animal models.

Keyphrases

gene expression
induced apoptosis
cell cycle arrest
dna methylation
genome wide
electronic health record
copy number
oxidative stress
machine learning
genome wide identification
cell proliferation
deep learning