Vasodilators activate TMEM16A channels in endothelial cells to reduce blood pressure.

Alejandro Mata-DaboinTessa A C GarrudCarlos Fernandez-PenaDieniffer Peixoto-NevesM Dennis LeoAngelica K BernardelliPurnima SinghKafait U MalikJonathan H Jaggar

Published in: bioRxiv : the preprint server for biology (2023)

Vasodilators stimulate TRPV4 channels, leading to calcium-dependent activation of nearby TMEM16A channels in ECs to produce arterial hyperpolarization, vasodilation and a reduction in blood pressure.

Keyphrases

blood pressure
endothelial cells
hypertensive patients
heart rate
type diabetes
neuropathic pain
blood glucose
vascular endothelial growth factor