Tangshen formula improves diabetic nephropathy in STZ-induced diabetes rats fed with hyper-methionine by regulating the methylation status of kidney.
Yongwei JiangGuoXiong DengChengyin LiuHan TangJing ZhengXiaomu KongMeimei ZhaoYi LiuPeng GaoTianbao LiHailing ZhaoYongtong CaoPing LiLiang MaPublished in: Clinical epigenetics (2024)
While HM exacerbates DN through altered methylation patterns at specific CpG sites, TSF holds promise as a viable treatment for DN by restoring abnormal methylation levels. The identification of specific genes provides valuable insights into the underlying mechanisms of DN pathogenesis and offers potential therapeutic targets for further investigation.
Keyphrases
- genome wide
- diabetic nephropathy
- dna methylation
- diabetic rats
- type diabetes
- cardiovascular disease
- bioinformatics analysis
- high glucose
- oxidative stress
- gene expression
- big data
- glycemic control
- human milk
- risk assessment
- combination therapy
- human health
- endothelial cells
- transcription factor
- artificial intelligence
- skeletal muscle
- preterm birth