Neurodegeneration, Heterochromatin, and Double-Stranded RNA.
Tassa K SaldiPatrick K GonzalesThomas J LaRoccaChristopher D LinkPublished in: Journal of experimental neuroscience (2019)
Changes in chromatin and epigenetic modifications have been associated with aging and aging-associated neurodegenerative diseases, although the causal relationship between these changes and disease-related pathology has been unclear. Recent studies have now made direct connections between neurodegeneration-associated proteins and derepression of repetitive element transcription due to changes in heterochromatin. We suggest that this derepression leads to an increased accumulation of intracellular double-stranded RNA (dsRNA), with an attendant induction of innate immune responses that contribute to the neuroinflammation found in essentially all age-associated neurodegenerative diseases.
Keyphrases
- immune response
- nucleic acid
- gene expression
- binding protein
- transcription factor
- dna methylation
- dna damage
- traumatic brain injury
- high frequency
- dendritic cells
- toll like receptor
- genome wide
- cognitive impairment
- reactive oxygen species
- lps induced
- oxidative stress
- blood brain barrier
- cerebral ischemia
- inflammatory response
- subarachnoid hemorrhage
- drug induced