Chronic isolation stress is associated with increased colonic and motor symptoms in the A53T mouse model of Parkinson's disease.

Shanti DiwakarlaDavid I FinkelsteinRemy ConstableOlivia ArtaizMadeleine Di NataleRachel M McQuadeEnie LeiXin-Yi ChaiMitchell T RinguetLinda J FothergillVictoria A LawsonLaura J EllettJoel P BergerJohn Barton Furness

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2019)

Chronic isolation stress exacerbates PD-associated GI dysfunction, in addition to increasing motor deficits. However, these changes in GI symptoms are not directly related to corticosterone levels, worsened enteric neuropathy, or enteric αsyn accumulation.

Keyphrases

mouse model
traumatic brain injury
sleep quality
stress induced
depressive symptoms