Dysregulation of the endothelial nitric oxide pathway is associated with airway inflammation in COPD.
Balázs CsomaAndrás BikovLajos NagyBence TóthTamás TábiGergő SzűcsZsolt István KomlósiVeronika MüllerGyörgy LosonczyZsófia LázárPublished in: Respiratory research (2019)
Our data suggest impaired eNOS function in stable COPD, which is transiently aggravated during an exacerbation and partly reversed by systemic steroid treatment. Serum ADMA and SDMA correlate with airway inflammatory markers implying a possible effect of anti-inflammatory therapy on endothelial dysfunction. Serum nitrite can serve as a compensatory pool for impaired endothelial NO generation.
Keyphrases
- chronic obstructive pulmonary disease
- nitric oxide
- endothelial cells
- nitric oxide synthase
- lung function
- anti inflammatory
- hydrogen peroxide
- electronic health record
- pi k akt
- big data
- stem cells
- intensive care unit
- cell proliferation
- signaling pathway
- combination therapy
- air pollution
- replacement therapy
- acute respiratory distress syndrome
- artificial intelligence
- data analysis
- mechanical ventilation