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Impact of Innate Immunity, Endothelial Damage, and Metabolic Biomarkers on COVID-19 Severity and Mortality.

Joseph M RoccoPaola LaghettiMariantonietta Di StefanoIrini SeretiAna Ortega-VillaJing WangAdam RupertMaria ChironnaLara YeXiangdong LiuMegan V AndersonPeter B BurbeloJose Ramon FioreAnnalisa SaracinoAndrea Lisco
Published in: Open forum infectious diseases (2022)
In this study, abnormal levels of myeloid activation, endothelial damage, and innate immune markers were associated with severe coronavirus disease 2019 (COVID-19), while higher levels of metabolic biomarkers (irisin, leptin) demonstrated a protective effect. These data support a model for COVID-19 immunopathogenesis linking robust inflammation and endothelial damage in metabolically predisposed individuals.
Keyphrases
  • coronavirus disease
  • oxidative stress
  • sars cov
  • endothelial cells
  • innate immune
  • respiratory syndrome coronavirus
  • acute myeloid leukemia
  • early onset
  • dendritic cells
  • cardiovascular disease
  • immune response