MR-guided focused ultrasound increases antibody delivery to nonenhancing high-grade glioma.
Caterina BrighiLee ReidAlison L WhiteLaura A GenovesiMarija KojicAmanda MillarZara BruceBryan W DayStephen RoseAndrew K WhittakerSimon PuttickPublished in: Neuro-oncology advances (2020)
FUS exposure successfully allowed temporary BBB disruption, localized to specifically targeted, nonenhancing, infiltrating tumor regions and delivery of a systemically administered antibody was significantly increased.