Hallux Valgus, By Nature or Nurture? A Twin Study.

Shannon E MunteanuHylton B MenzJohn D WarkJemma J ChristieKatrina J ScurrahMinh BuiBircan ErbasJohn L HopperAnita E Wluka

Published in: Arthritis care & research (2017)

Twins are correlated for HV, but we found no evidence that correlation was due to shared genetic factors. We identified an environmental risk factor, footwear with a constrictive toe-box, that is not shared to the same extent by MZ and DZ pairs, contrary to the assumption of the classic twin model. Footwear, and possibly genetic factors and unknown shared environmental factors, could contribute to developing HV.

Keyphrases

genome wide
risk factors
copy number
transcription factor
gene expression
dna methylation
binding protein
human health
gestational age