Shared and Distinct Renal Transcriptome Signatures in 3 Standard Mouse Models of Chronic Kidney Disease.
Adam B Marstrand-JørgensenFrederikke Emilie SembachStine Thorhauge BakMaria OugaardMikkel Christensen-DalsgaardMartin Rønn MadsenDitte Marie JensenThomas SecherSebastian Møller Nguyen HeimbürgerLisbeth N FinkDitte HansenHenrik H HansenMette Viberg ØstergaardMichael ChristensenLouise S DalbøgePublished in: Nephron (2024)
The UUO, uIRI, and ADI mouse models of CKD have significant commonalities in their renal global transcriptome profile. Model-specific renal transcriptional signatures should be considered when selecting the specific model in preclinical target and drug discovery.