HFIP-Promoted Bischler Indole Synthesis under Microwave Irradiation.
Guangkai YaoZhi-Xiang ZhangCheng-Bei ZhangHan-Hong XuRi-Yuan TangPublished in: Molecules (Basel, Switzerland) (2018)
1,1,1,3,3,3-Hexafluoropropan-2-ol (HFIP) was found to be effective for the Bischler indole synthesis under microwave irradiation in the absence of a metal catalyst. Under the catalysis of HFIP, a wide range of α-amino arylacetones were successfully transformed into indole derivatives with moderate to good yields.