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A compact targeted drug delivery mechanism for a next generation wireless capsule endoscope.

Stephen P WoodsTimothy G Constandinou
Published in: Journal of micro-bio robotics (2016)
This paper reports a novel medication release and delivery mechanism as part of a next generation wireless capsule endoscope (WCE) for targeted drug delivery. This subsystem occupies a volume of only 17.9mm3 for the purpose of delivering a 1 ml payload to a target site of interest in the small intestinal tract. An in-depth analysis of the method employed to release and deliver the medication is described and a series of experiments is presented which validates the drug delivery system. The results show that a variable pitch conical compression spring manufactured from stainless steel can deliver 0.59 N when it is fully compressed and that this would be sufficient force to deliver the onboard medication.
Keyphrases
  • drug delivery
  • cancer therapy
  • adverse drug
  • healthcare
  • low cost
  • drug release
  • single molecule
  • emergency department
  • magnetic resonance
  • image quality
  • contrast enhanced