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Mammalian D-Cysteine: A new addition to the growing family of biologically relevant D-amino acids.

Robin Roychaudhuri
Published in: Chirality (2023)
Mammalian D-Cysteine is racemized from L-cysteine by serine racemase, a pyridoxal phosphate (PLP)-dependent enzyme. Endogenous D-Cysteine plays a role in neural development by inhibiting proliferation of neural progenitor cells (NPCs) via protein kinase B (AKT) signaling mediated by the FoxO family of transcription factors. D-Cysteine binds to Myristoylated Alanine Rich C Kinase Substrate (MARCKS) and alters phosphorylation at Ser 159/163 and its translocation from the membrane. By racemizing serine and cysteine, mammalian serine racemase may play important roles in neural development highlighting its importance in psychiatric disorders.
Keyphrases
  • protein kinase
  • fluorescent probe
  • living cells
  • signaling pathway
  • transcription factor
  • amino acid
  • tyrosine kinase
  • structural basis