Nickel-catalyzed hydrodefluorination/deuterodefluorination of CF 3 -alkenes with formic acid.
Peng YangHaiping YuRunze ZhaiJianrong Steve ZhouBo TangPublished in: Chemical communications (Cambridge, England) (2024)
The synthesis of deuterated gem -difluoroalkenes via selective deuterodefluorination of β-CF 3 -cinnamates using a nickel catalyst has been reported for the first time. Commercially available deuterated formic acid is a cheap and convenient deuterium source. The nickel-catalyst showed high selectivity for monodefluorination and avoided competitive reactions such as multiple defluorination or hydrogenation.