Stimulation of Angiotensin II Type 2 Receptor Modulates Pro-Inflammatory Response in Microglia and Macrophages: Therapeutic Implications for the Treatment of Stroke.
Abdulkarim AlshammariYohan HanTimothy W JonesBindu PillaiDuo ZhangAdviye ErgulPayaningal R SomanathSusan C FaganPublished in: Life (Basel, Switzerland) (2023)
Our findings suggest a protective effect of C21 against the inflammatory response, in both macrophages and microglia, via suppression of the release of pro-inflammatory cytokines/chemokines and the generation of ROS while stimulating the production of neurotrophic factors.