Human lung fibroblast-to-myofibroblast transformation is not driven by an LDH5-dependent metabolic shift towards aerobic glycolysis.

Eva SchrufVictoria SchroederChristian A KuttruffSabine WeigleMartin KrellMaryke BenzTom BretschneiderAlexander HolwegMichael SchulerManfred FrickPaul NicklinJames P GarnettMirko C Sobotta

Published in: Respiratory research (2019)

Our data strongly suggest that while LDH5 inhibition can prevent metabolic shifts in fibroblasts, it has no influence on FMT and therefore glycolytic dysregulation is unlikely to be the sole driver of FMT.

Keyphrases

electronic health record
high intensity
transforming growth factor
big data
extracellular matrix
epithelial mesenchymal transition