Relationship between mutations in severe hemophilia A and risk of inhibitor development: A large single-center study.

Arash Ahmadfard MoghadamAmir Reza ManafzadehM R NikooniaSeyedeh Somayeh MoazeziKhadijeh Dajliry NekoeiFarahnaz RamezanDavood BashashMohsen HamidpourShadi Tabibian

Published in: Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis (2024)

The results of this study confirm the important role of different genetic variants, family history of inhibitor formation, and history of intense injections for the formation of inhibitors in patients with severe HA. This would allow us to stratify the patients which can have important clinical implications, especially in terms of their management and outcome.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
early onset
peritoneal dialysis
prognostic factors
patient reported outcomes
ultrasound guided