Increase in Cardiac Ischemia-Reperfusion Injuries in Opa1+/- Mouse Model.

Sophie Le PageMarjorie NiroJérémy FauconnierLaura CellierSophie TamareilleAbdallah GharibArnaud ChevrollierLaurent LoufraniCéline GrenierRima KamelEmmanuelle SarziAlain LacampagneMichel OvizeDaniel HenrionPascal ReynierGuy LenaersDelphine Mirebeau-PrunierFabrice Prunier

Published in: PloS one (2016)

Opa1 deficiency was associated with increased sensitivity to I/R, imbalance in dynamic mitochondrial Ca2+ uptake, and subsequent increase in NCX activity.

Keyphrases

mouse model
oxidative stress
left ventricular
heart failure
replacement therapy