Hippocampal Interictal Spikes during Sleep Impact Long-Term Memory Consolidation.
Isabelle LambertEve Tramoni-NegreStanislas LagardeNicolas RoehriBernard GiusianoAgnès Trebuchon-Da FonsecaRomain CarronChristian-Georges BenarOlivier FelicianFabrice BartolomeiPublished in: Annals of neurology (2020)
Our results show that activation of interictal spikes in the hippocampus during sleep and seizures specifically impair long-term memory consolidation. We hypothesize that hippocampal interictal spikes during sleep interrupt hippocampal-neocortical transfer of information. ANN NEUROL 2020;87:976-987.