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Population pharmacokinetic analysis of dexmedetomidine in children using real-world data from electronic health records and remnant specimens.

Nathan T JamesJoseph H BreeyearRichard CaprioliTodd L EdwardsBrian HacheyPrince J KannankerilJacob M KeatonMatthew D MarshallSara L Van DriestLeena Choi
Published in: British journal of clinical pharmacology (2022)
Our study demonstrates the use of real-world EHR data and remnant specimens to perform a population pharmacokinetic analysis and investigate covariate effects in a large paediatric population. Weight and age were important predictors of clearance. We did not find evidence for pharmacogenetic effects of UGT1A4 or UGT2B10 genotype or CYP2A6 risk score.
Keyphrases
  • electronic health record
  • clinical decision support
  • emergency department
  • intensive care unit
  • young adults
  • body mass index
  • big data
  • physical activity
  • weight loss
  • weight gain
  • ultrasound guided