Population pharmacokinetic analysis of dexmedetomidine in children using real-world data from electronic health records and remnant specimens.
Nathan T JamesJoseph H BreeyearRichard CaprioliTodd L EdwardsBrian HacheyPrince J KannankerilJacob M KeatonMatthew D MarshallSara L Van DriestLeena ChoiPublished in: British journal of clinical pharmacology (2022)
Our study demonstrates the use of real-world EHR data and remnant specimens to perform a population pharmacokinetic analysis and investigate covariate effects in a large paediatric population. Weight and age were important predictors of clearance. We did not find evidence for pharmacogenetic effects of UGT1A4 or UGT2B10 genotype or CYP2A6 risk score.