Lidocaine inhibits vascular endothelial growth factor-A-induced angiogenesis.
Shogo SuzukiAtsushi MoriAya FukuiYoshiaki EmaKimitoshi NishiwakiPublished in: Journal of anesthesia (2020)
We demonstrated that lidocaine has an anti-angiogenesis effect on clinically effective blood concentrations without causing cell death. This finding could represent a new avenue for future research into anesthesia, cancer-related analgesia, and revascularization therapy.
Keyphrases
- vascular endothelial growth factor
- cell death
- endothelial cells
- high glucose
- diabetic rats
- current status
- pain management
- percutaneous coronary intervention
- coronary artery bypass grafting
- cell cycle arrest
- ultrasound guided
- drug induced
- coronary artery disease
- chronic pain
- acute coronary syndrome
- atrial fibrillation
- bone marrow
- stress induced
- pi k akt