Detection of gene-environment interactions in the presence of linkage disequilibrium and noise by using genetic risk scores with internal weights from elastic net regression.
Anke HülsKatja IckstadtTamara SchikowskiUrsula KrämerPublished in: BMC genetics (2017)
In conclusion, weighted GRS with weights from the marginal genetic effects of the SNPs estimated by a multivariate elastic net regression were shown to be a powerful tool to detect gene-environment interactions in scenarios of high Linkage disequilibrium and noise.
Keyphrases
- genome wide
- dna methylation
- copy number
- air pollution
- climate change
- magnetic resonance
- gene expression
- magnetic resonance imaging
- computed tomography
- network analysis
- hiv testing
- hepatitis c virus
- label free
- men who have sex with men
- human immunodeficiency virus
- contrast enhanced
- quantum dots
- transcription factor
- hiv infected