Nitidine chloride represses Mcl-1 protein via lysosomal degradation in oral squamous cell carcinoma.

In-Hyoung YangWon JungLee-Han KimJi-Ae ShinNam-Pyo ChoSeong Doo HongKyoung-Ok HongSung-Dae Cho

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2018)

Our findings suggest that NC triggers apoptosis via lysosome-dependent Mcl-1 protein degradation and could be chosen as a promising chemotherapeutic candidate against human OSCCs.

Keyphrases

endothelial cells
protein protein
oxidative stress
amino acid
endoplasmic reticulum stress
cell death
binding protein
induced pluripotent stem cells
cell cycle arrest
single molecule