Chromatin dynamics during the differentiation of long-term hematopoietic stem cells to multipotent progenitors.

Juan R Alvarez-DominguezChao WuDheeraj BhavanasiHong WangBrian D GregoryJian Huang

Published in: Blood advances (2017)

ATAC-seq provides genome-wide chromatin state in 3 cell types of hematopoietic stem/progenitor cells.Transcription factor cohorts are associated with dynamic changes of open chromatin during the differentiation of LT/ST-HSCs to MPPs.

Keyphrases

genome wide
transcription factor
dna methylation
induced apoptosis
gene expression
copy number
dna damage
single cell
cell cycle arrest
dna binding
cell therapy
minimally invasive
stem cells
signaling pathway
cell proliferation
mesenchymal stem cells