TRIM26 inhibits hepatitis B virus replication by promoting HBx degradation and TRIM26 genetic polymorphism predicts PegIFNα treatment response of HBeAg-positive chronic hepatitis B Patients.

Mengqi LuoJia HouHaoming MaiJiaxuan Chen Haitao ChenBin ZhouJin-Lin Hou De-Ke Jiang

Published in: Alimentary pharmacology & therapeutics (2022)

TRIM26 inhibits HBV replication; IFN promotes TRIM26 expression. TRIM26 exerts an inhibitory effect on HBx by promoting ubiquitin-mediated degradation of HBx. Furthermore, TRIM26 rs116806878 is a potential predictive biomarker of response to PegIFNα in patients with CHB.

Keyphrases

hepatitis b virus
liver failure
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
gene expression
genome wide
peritoneal dialysis
dendritic cells
climate change