The protein phosphatase PP6 promotes RIPK1-dependent PANoptosis.
Ratnakar R BynigeriR K Subbarao MalireddiRaghvendra MallJon P ConnellyShondra M Pruett-MillerThirumala-Devi KannegantiPublished in: BMC biology (2024)
Overall, our findings demonstrate a key requirement for the phosphatase PP6 complex in the activation of TAK1i-induced, RIPK1-dependent PANoptosis, suggesting this complex could be therapeutically targeted in inflammatory conditions.