Understanding the cellular and molecular determinants of mammalian tissue regeneration and repair is crucial for developing effective therapies that restore tissue architecture and function. In this review, we focus on the cell types involved in scarless wound response and regeneration of spiny mice (Acomys). Comparative -omics approaches with scar-prone mammals have revealed species-specific peculiarities in cellular behavior during the divergent healing trajectories. We discuss the developing views on which cell types engage in restoring the architecture of spiny mouse tissues through a co-ordinated spatiotemporal response to injury. While yet at the beginning of understanding how cells interact in these fascinating animals to regenerate tissues, spiny mice hold great promise for scar prevention and anti-fibrotic treatments.
Keyphrases
- single cell
- stem cells
- wound healing
- cell therapy
- gene expression
- induced apoptosis
- high fat diet induced
- systemic sclerosis
- idiopathic pulmonary fibrosis
- bone marrow
- adipose tissue
- endoplasmic reticulum stress
- oxidative stress
- skeletal muscle
- mesenchymal stem cells
- insulin resistance
- signaling pathway
- surgical site infection