Effect of polygenic risk score, family load of schizophrenia and exposome risk score, and their interactions, on the long-term outcome of first-episode psychosis.

Manuel J CuestaS PapiolB IbañezE García de JalónA M Sánchez-TorresG J Gil-BerrozpeL Moreno-IzcoA ZarzuelaL FañanásV Peraltanull null

Published in: Psychological medicine (2023)

Our results support an additive model of familial antecedents of schizophrenia, environmental risk factors and polygenic risk factors as contributors to a poor long-term functional outcome for FEP patients.

Keyphrases

risk factors
bipolar disorder
end stage renal disease
ejection fraction
newly diagnosed
prognostic factors
early onset
risk assessment