Generation of induced pluripotent stem cells from large domestic animals.

Fabiana Fernandes BressanVinícius BassanezzeLaís Vicari de Figueiredo PessôaChester Bittencourt SacramentoTathiane Maistro MaltaSimone KashimaPaulo Fantinato NetoRicardo De Francisco StrefezziNaira Caroline Godoy PieriJosé Eduardo KriegerDimas Tadeu CovasFlávio Vieira Meirelles

Published in: Stem cell research & therapy (2020)

The generation of reproducible protocols in different animal species will provide an informative tool for producing in vitro autologous pluripotent cells from domestic animals. These cells will create new opportunities in animal breeding through transgenic technology and will support a new era of translational medicine with large animal models.

Keyphrases

induced pluripotent stem cells
induced apoptosis
cell cycle arrest
bone marrow
cell therapy
stem cells
endoplasmic reticulum stress
oxidative stress
platelet rich plasma
cell proliferation