Dichotomous effects on lymphatic transport with loss of caveolae in mice.
Gaurav BaranwalHeidi A CreedWalter E CromerWei WangBradley D UpchurchMatt C SmithhartSuman S VadlamaniMary-Catherine C ClarkNapoleon C BusbusoStephanie N BlaisAndrea J ReynaRanjeet M DongaonkarDavid C ZawiejaJoseph M RutkowskiPublished in: Acta physiologica (Oxford, England) (2021)
Macromolecule transport across lymphatics is increased with loss of caveolae, yet phasic contractility reduced, resulting in reduced overall lymphatic transport function. These studies identify lymphatic caveolar biology as a key regulator of active lymphatic transport functions.