Detecting Neurodevelopmental Effects of Early-Gestation Ethanol Exposure: A Nonhuman Primate Model of Ethanol Drinking During Pregnancy.
Vanessa A JimenezXiaojie WangNatali NewmanNicole A R WalterSteven GonzalesJamie O LoMathew M FordVerginia C Cuzon CarlsonKathleen A GrantChristopher D KroenkePublished in: Alcoholism, clinical and experimental research (2019)
This FASD model takes advantage of the similarities between humans and rhesus macaques in gestational length relative to brain development, as well as similarities in EtOH self-administration and metabolism. The daily 1.5 g/kg dose of EtOH through the first trimester does not influence pregnancy success rates. However, pregnancy influences drinking behavior during the second month of pregnancy. Future publications using this model will describe the effect of early-gestation EtOH exposure on anatomical and functional brain development at subsequent gestational ages.