Relationship between intestinal flora structure and metabolite analysis and immunotherapy efficacy in Chinese NSCLC patients.

Peng SongDongliang YangHanping Wang Xiaoxia Cui Xiao-Yan Si Xiao-Tong ZhangLi Zhang

Published in: Thoracic cancer (2020)

We found a close correlation between intestinal microbiome β-diversity and anti-PD-1 immunotherapy response in Chinese patients with advanced NSCLC. The intestinal flora composition, functional group protein family, and KEGG metabolism also differed between the two groups. Differences in pathways and flora metabolites were also noted.

Keyphrases

small cell lung cancer
end stage renal disease
newly diagnosed
ejection fraction
ms ms
peritoneal dialysis
prognostic factors
small molecule
protein protein
amino acid
epidermal growth factor receptor