EZH2-H3K27me3-mediated silencing of mir-139-5p inhibits cellular senescence in hepatocellular carcinoma by activating TOP2A.

Ke WangXunliang JiangYu JiangJun LiuYongtao DuZecheng ZhangYunlong LiXinhui ZhaoJipeng LiRui Zhang

Published in: Journal of experimental & clinical cancer research : CR (2023)

Our study revealed the role of the EZH2/miR-139-5p/TOP2A axis in regulating cellular senescence and cell proliferation in HCC, enriching the molecular mechanisms of EZH2-mediated epigenetic regulation in HCC. Therefore, our results provide insight into the therapeutic potential of targeting EZH2 to induce cellular senescence and then destroy senescent cells for HCC.

Keyphrases

long noncoding rna
long non coding rna
dna damage
endothelial cells
cell proliferation
induced apoptosis
stress induced
signaling pathway
cell cycle arrest
oxidative stress
cell death