A new perspective in cancer immunotherapy: PD-1 on myeloid cells takes center stage in orchestrating immune checkpoint blockade.

Published in: Science immunology (2020)

PD-1 mediates antitumor immunity by regulating lineage fate commitment and function of myeloid cells (see related Research Article by Strauss et al..).

Keyphrases

induced apoptosis
cell cycle arrest
dendritic cells
bone marrow
acute myeloid leukemia
endoplasmic reticulum stress
signaling pathway
cell death
immune response
cell proliferation
pi k akt